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KMID : 0377220020270020028
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Medical Journal of Chosun Univercity
2002 Volume.27 No. 2 p.28 ~ p.32
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Expression patterns of bcl-2 oncoprotein in squamous intraepithelial lesions and invasive squamous cell carcinoma of uterine cervix
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Sung Jung-Hee
Oh Soo-Sup
Kee Keun-Hong
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Abstract
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Background and Objectives: Squamous cell carcinomas (SCC) of the uterine cervix arise from the carcinoma in situ developed in a field of atypical squamous cell proliferation. So, clinical significance of the cervical intraepithelial neoplasm (CIN) are widely accepted. The purpose of this study is to investigate the oncoprotein changes in the sequence of low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), keratinizing type of squamous cell carcinoma (K-SCC) and nonkeratinizing type of squamous cell carcinoma (NK-SCC).
Materials and Methods: Immunohistochemical stains for anti-bcl-2 oncoprotein to 120 conized cervical tiussues or resected uterus specimens diagnosed as squamous cell lseions including 30 cases of LSIL, 30 cases of HSIL, 30 cases of K-SCC, and 30 cases of NK-SCC were done. The evaluation of the bcl-2 immunostaining was based on the percentages of the positive neoplastic cells. And statistical analysis of data for the relation between each lesion was performed using the Student t-test.
Results: The average positive cell rate was 2.0%, 4.44%, 6.25% and 13.57% in LSIL, HSIL, K-SCC, and NK-SCC, respectively. Statistically, immunoreactive positive cell rate of NK-SCC was significantly higher than those of LSIL (p=0.007) and HSIL (p=0.031). But, there was no significant difference of immunoreactive cell rate between K-SCC and HSIL.
Conclusion: These results suggested that bcl-2 may play a role in a cervical tumorigenesis and prognostic relationship with NK-SCC.
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KEYWORD
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bcl-2 oncoprotein, uterine cervix, squamous cell carcinoma
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